Question

question 19

a pharmacy technician is reviewing a prescription for a patient with renal impairment. the technician should recognize that which of the following types of medications may require dose adjustment in patients with decreased kidney function?

otc vitamins and mineral supplements
topical medications applied to intact skin
medications metabolized entirely by the liver

Explanation:

Analyze the physiological condition

Renal impairment refers to a decrease in kidney function, which directly affects how the body eliminates drugs.

Evaluate drug elimination routes

Drugs are primarily cleared from the body through either hepatic metabolism (liver) or renal excretion (kidneys).

Assess the options

• OTC vitamins and mineral supplements generally do not require strict renal dose adjustments unless they contain specific elements like potassium or phosphorus in severe cases.
• Topical medications applied to intact skin have minimal systemic absorption and do not require renal adjustment.
• Medications metabolized entirely by the liver rely on hepatic clearance, so their elimination is largely unaffected by kidney function.
• Medications that are primarily renally excreted rely on the kidneys for removal. Decreased kidney function leads to drug accumulation and toxicity, requiring dose reduction.

Answer:

• OTC vitamins and mineral supplements
• Topical medications applied to intact skin
• Medications metabolized entirely by the liver
• Medications that are primarily renally excreted (Correct answer)