a person has inherited the following genes:

le/le, se/se

what lewis antibody(ies) could they form?

anti-leb only
none
anti-lea only
anti-lea and anti-leb

Question

a person has inherited the following genes:

le/le, se/se

what lewis antibody(ies) could they form?

anti-leb only
none
anti-lea only
anti-lea and anti-leb

Accepted Answer

{ "quality": "clear", "question_count": 1, "skills_matched": [ "direct_cot", "multiple_choice_formatter", "explain_then_answer", "tutor", "mastery_adaptive_brevity" ], "needs_drawing": false, "concepts_used": [ "Lewis Blood Group", "Lewis Antigen Biosynthesis", "Lewis Phenotypes", "Lewis Antibodies" ], "new_concepts": [], "current_concepts": [ "Lewis Blood Group", "Lewis Antigen Biosynthesis", "Lewis Phenotypes", "Lewis Antibodies" ] } ## Analyze the inherited genotype Using the *Lewis Blood Group* and *Lewis Antigen Biosynthesis* knowledge points $$ \begin{aligned} &\text{Genotype: } le/le,\ Se/se \ &\text{FUT3 (Lewis transferase): Inactive (homozygous recessive } le/le\text{)} \ &\text{FUT2 (Secretor transferase): Active (heterozygous } Se/se\text{)} \end{aligned} $$ ## Determine the red cell phenotype Using the *Lewis Phenotypes* knowledge point $$ \begin{aligned} &\text{Since } le/le \text{ lacks functional fucosyltransferase 3, no Le}^{\text{a}}\text{ or Le}^{\text{b}}\text{ antigens are synthesized.} \ &\text{Red Cell Phenotype: } \text{Le(a-b-)} \end{aligned} $$ ## Determine potential antibody formation Using the *Lewis Antibodies* knowledge point $$ \begin{aligned} &\text{Individuals with the Le(a-b-) phenotype do not possess Le}^{\text{a}}\text{ or Le}^{\text{b}}\text{ antigens.} \ &\text{Consequently, they can recognize both antigens as foreign and produce both anti-Le}^{\text{a}}\text{ and anti-Le}^{\text{b}}\text{.} \end{aligned} $$

Anti-Leb only

none

Anti-Lea only

Anti-Lea and anti-Leb

{ "subject": "Natural Science", "question_type": "Multiple Choice", "knowledge_point": [ "Natural Science", "Medicine", "Immunohematology" ] }

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QUESTION IMAGE

Question

Explanation:

Analyze the inherited genotype

Determine the red cell phenotype

Determine potential antibody formation

Answer: