Question

multiple choice 1 point
which of the following nucleophiles would likely result in the fastest s_n2 reaction with an alkyl halide?
h_2o
ch_3oh
nh_3
koh
previous

Explanation:

Step1: Determine nucleophilicity

In \(S_N2\) reactions, stronger nucleophiles react faster. Nucleophilicity is related to basicity (in protic solvents). \(H_2O\) and \(CH_3OH\) are neutral molecules (weak nucleophiles as they have less tendency to donate electrons). \(NH_3\) is a neutral molecule (nucleophilic due to lone pair on N but less basic than \(OH^-\)). \(KOH\) dissociates to give \(OH^-\) (strong base, strong nucleophile as it has a negative charge and high electron - density ready to attack the electrophilic carbon in alkyl halide).

Answer:

KOH