Question

how did the spanish most exploit the indigenous peoples of the americas?
by enslaving them and forced them to work in mines and on plantations
by paying them poorly for working in mines and on plantations
by bringing them back to europe as enslaved people
by setting up a large - scale hunting operation to kill all of the bison

Explanation:

The Spanish enslaved Indigenous peoples and forced them into labor in mines and on plantations. Paying poorly (if at all) was part of the exploitation, but enslavement was the main method. Bringing them to Europe was less common compared to local exploitation. The bison - hunting operation was more associated with later American settlers, not the Spanish exploitation of Indigenous Americans.

Answer:

by enslaving them and forced them to work in mines and on plantations