Question

which of the following medications should be compounded in a biological safety cabinet?

methotrexate
ondansetron
ampicillin
potassium chloride

question 24

a pharmacy technician is performing continuous sterile compounding. how often should the technician clean her work surface during this process?

every 60 min
every 15 min
every 30 min
every 45 min

Explanation:

Identify the hazardous drug requiring a biological safety cabinet

Using the Biological Safety Cabinet knowledge point

• A biological safety cabinet (BSC) provides vertical laminar airflow and negative pressure to protect the operator and environment from hazardous drug exposure.
• Among the choices (Methotrexate, Ondansetron, Ampicillin, Potassium chloride), Methotrexate is a hazardous antineoplastic agent (chemotherapy drug) classified by NIOSH.
• Therefore, Methotrexate must be compounded in a BSC to ensure personnel safety.

Determine sanitization frequency during continuous sterile compounding

Using the Sanitization Frequency knowledge point

• Under USP <797> regulations, during continuous compounding operations, the work surface of the laminar airflow workbench or compounding hood must be cleaned and disinfected regularly.
• The standard frequency requirement for sanitizing the work surface during ongoing, continuous compounding is at least every 30 minutes.
• It must also be cleaned at the beginning of each shift, before each batch, after spills, or when contamination is suspected.

Answer:

Question 1

• Methotrexate (Correct answer)
• Ondansetron
• Ampicillin
• Potassium chloride

Question 2

• Every 60 min
• Every 15 min
• Every 30 min (Correct answer)
• Every 45 min