Question

at what point during the cell cycle do chromosomes initially consist of two sister chromatids?
prophase
metaphase
anaphase
telophase
interphase

Explanation:

During interphase, DNA replication occurs in the S - phase. This replication results in each chromosome initially consisting of two sister chromatids. Prophase is when chromosomes condense and become visible. Metaphase is when chromosomes align at the equatorial plate. Anaphase is when sister chromatids separate. Telophase is the final stage of mitosis where the nuclear envelope reforms. So the key is that DNA replication (which gives sister chromatids) happens in interphase.

Answer:

E. Interphase