Question

researchers often use mice to evaluate potential medications for treating human disease. if a medication is successful in the mouse model, it then must be further tested in human clinical trials. which of the following best explains why clinical trials are necessary?
○ mice and humans evolved independently of one another.
○ mice and humans have only 80% genetic similarity.
○ mice and humans have very different biochemistries.
○ mice are much smaller than humans.
○ mice and humans live in different environments.

Explanation:

Clinical trials are necessary because even if a medication works in mice, differences in biochemical processes (e.g., metabolism, drug interaction pathways) between mice and humans mean its efficacy or safety may not translate directly. Other options are incorrect: mice and humans share ~90% genetic similarity (not 80%), evolved from a common ancestor, size/environment differences are less critical than biochemical differences for drug response.

Answer:

Mice and humans have very different biochemistries.