Question

question 5 (mandatory) (2 points) listen a 62 - year - old man has had increasing difficulty with voluntary movements because of muscular rigidity. on physical exam he has difficulty initiating movement, but he can keep moving if he follows someone walking ahead of him. he has an expressionless face. when sitting alone his hands have a \pill - rolling\ tremor. which pathologic finding in the brain is most likely to be found? the presence of hirano bodies in the basal nuclei loss of pigmented neurons in the midbrain hippocampal neurofibrillary tangles neuronal loss with gliosis in the caudate nucleus

Explanation:

The patient shows symptoms of Parkinson's disease such as muscular rigidity, difficulty initiating movement, expressionless face, and pill - rolling tremor. Parkinson's is characterized by the loss of pigmented neurons (specifically dopaminergic neurons) in the substantia nigra of the midbrain. Hirano bodies are associated with Alzheimer's and other neurodegenerative diseases. Hippocampal neurofibrillary tangles are typical of Alzheimer's. Neuronal loss with gliosis in the caudate nucleus is related to Huntington's disease.

Answer:

Loss of pigmented neurons in the midbrain