Question

question 8 (mandatory) (1.25 points)
a mutation leads to a g protein that can no longer bind to its associated gpcr. what would be the consequence for the signaling pathway?
the gpcr would remain constitutively active.
the g protein would be permanently activated by the non - binding gpcr.
the gpcr would be unable to initiate the next step of the transduction cascade.
the downstream effectors would remain permanently active

Explanation:

G proteins normally inactivate after signaling. If a G protein can’t bind to its associated GPCR (to be inactivated), it stays active, leading to permanent downstream effector activation. Other options: GPCR activation isn’t directly affected, G protein activation isn’t from non - binding GPCR, and GPCR can still initiate signaling.

Answer:

The downstream effectors would remain permanently active