Question

a nurse is reviewing the pharmacokinetics of medications with a newly licensed nurse. the nurse should include that which of the following factors can affect the rate of absorption? (select all that apply.) age of the client first pass effect lipid solubility of a medication route of administration metabolism of the medication

Explanation:

• Age of the client: Different age groups (e.g., infants, elderly) have variations in physiological processes (like gastric pH, blood flow to tissues) that impact drug absorption.
• Lipid solubility of a medication: Lipid - soluble drugs can cross cell membranes (like the lipid - based cell membranes) more easily, affecting how quickly they are absorbed.
• Route of administration: Different routes (e.g., oral, intravenous, intramuscular) have different rates of absorption. For example, intravenous administration has immediate absorption, while oral administration may be slowed by factors like gastric emptying.
• The "First pass effect" and "Metabolism of the medication" are related to drug metabolism (not absorption). The first - pass effect occurs when a drug is metabolized in the liver before reaching systemic circulation (affects bioavailability, not absorption rate directly). Metabolism of the medication is about the breakdown of the drug, not its absorption.

Answer:

• Age of the client
• Lipid solubility of a medication
• Route of administration