Question

negative selection of naive t cells in the thymus is essential for which of the following?
answers: a - d
a removal (apoptosis) of t cells that react with self antigens
b selection of t cells that react with self antigens
c removal (apoptosis) of t cells that do not recognize self mhc molecules
d selection of t cells that recognise self mhc molecules

Explanation:

Negative selection in the thymus is a process where T cells that react with self - antigens are removed (by apoptosis). This is crucial for preventing autoimmune diseases. Option B is incorrect as it is about selection (not removal) of T cells reacting with self - antigens. Option C is about T cells not recognizing self MHC molecules, which is related to positive selection (not negative selection). Option D is about selection of T cells recognizing self MHC molecules (positive selection).

Answer:

A. Removal (apoptosis) of T cells that react with self antigens