Question

would a mutation in an enzyme that changes its active site subsequently change the function of the enzyme?
no, because another enzyme would make up for it.
yes, because the active site binds specifically to the substrate to carry out the reaction.
no, because the shape of the active site really does not matter.
no, because the enzyme would probably bind to the substrate anyway.

Explanation:

The active site of an enzyme has a specific shape that allows it to bind to its substrate (lock-and-key model). A mutation changing the active site disrupts this specific binding, so the enzyme can no longer perform its function. Other options are incorrect: active site shape is critical, another enzyme doesn’t inherently compensate, and the enzyme won’t bind the substrate without the correct active site shape.

Answer:

Yes, because the active site binds specifically to the substrate to carry out the reaction.