Question

multiple choice question
linkage maps constructed by collecting data from many human families can allow us to identify genes responsible for certain diseases; however, discovery based on linkage analysis is generally limited to ______.

• disorders caused by snps
• single - gene disorders
• disorders caused by large chromosomal aberrations
• polymorphic disorders

Explanation:

Linkage analysis tracks gene inheritance in families. It is most effective for disorders where a single gene mutation has a large effect (single-gene disorders), as polygenic/polymorphic traits or SNPs involve multiple small effects hard to detect via family linkage. Large chromosomal aberrations are usually identified via cytogenetics, not linkage.

Answer:

single-gene disorders