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Question
an immunoassay was developed to rapidly diagnose patients infected with an emerging virus. however, the researchers discovered that some individuals were producing false negatives when tested, despite being infected with the virus. what might explain this? multiple choice rapid evolution of the viral antigen changes in the antibody produced by the virus number of genome copies carried in each virion changes in the length of the viral dna
Immunoassays rely on the recognition of viral antigens by antibodies. If the viral antigen evolves rapidly, the antibodies in the immunoassay may not be able to bind effectively, leading to false - negatives. Viruses don't produce antibodies. The number of genome copies per virion and changes in viral DNA length don't directly affect the antibody - antigen interaction in an immunoassay in the way that antigen evolution does.
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A. Rapid evolution of the viral antigen