Question

drag and drop the terms to correctly complete the table.
missense mutation
nonsense mutation
silent mutation
original dna
sequence
atg ggc
tat acg
atg ggc
tat acg
atg ggc
tat acg
original
mrna
sequence
uac ccg
aua ugc
uac ccg
aua ugc
uac ccg
aua ugc
original
amino acid
sequence
met-gly-
phe-thr
met-gly-
thr
met-gly-
thr
mutated
dna
sequence
atg ggc
acg
atg ggc
acg
atg ggc
taa acg
mutated
mrna
sequence
uac ccg
aua ugc
uac cca
aua ugc
uac ccg
auu ugc
mutated
amino acid
sequence
met-val-phe-
thr
met-gly-tyr-
thr
met-gly-
stop
type of
mutation

Explanation:

• For the first mutation (ATG GTC TAT → UAC CAG AUA UGC): Since the amino - acid sequence changes (Met - Gly - Tyr - Thr in original and Met - Val - Phe - Thr in mutated), it is a missense mutation.
• For the second mutation (ATG GGT TAT → UAC CCA AUA UGC): The amino - acid sequence has a change (Met - Gly - Tyr - Thr in original and Met - Gly - Tyr - Thr in mutated, but looking at the codon change, it is a silent mutation as the amino - acid sequence for Thr is still coded (AUA UGC for Thr in both cases, and the change in the DNA (GGC→GGT) leads to a codon change (CCG→CCA) which codes for the same amino - acid (Gly is still Gly as CCG and CCA can code for Gly in some cases, and Thr codons remain the same in terms of amino - acid output).
• For the third mutation (TAA ACG → UAC CCG AUU UGC): The codon AUU is a stop codon (in the context of translation, AUU can be a non - sense codon as it prematurely terminates the protein synthesis), so it is a nonsense mutation.

Answer:

• First blank: Missense Mutation
• Second blank: Silent Mutation
• Third blank: Nonsense Mutation